宋关玲
学位:博士研究生
职称:教授
研究领域:环境污染物的毒性机制;新疆特色抗癌药物筛选
邮箱:sglhit.student@sina.com
办公电话:0993-2057153
通讯地址:石河子大学医学院杏1楼办公室733号
学术兼职情况:
华中科技大学兼职博导
中国毒理学会会员
新疆营养学会理事
科研学术工作经历与教育背景:
2017-11 至今, 石河子大学, 医学院, 教授
2014-01 至2017-11, 石河子大学, 医学院, 副教授
2007-01 至2014-01, 山东理工大学, 生命科学学院, 副教授
2002-03 至2005-10,哈尔滨工业大学市政环境工程学院环境工程专业,博士学位
科研项目:
主持国家自然科学基金项目3项,省级项目2项、校级项目3项,横向课题4项;参与国家重大水利专项、国家973项目、中日国际合作项目和国家自然科学基金项目共6项。
目前主持在研项目如下:
国家自然科学基金项目:MCUC在纳米二氧化钛致血睾屏障破坏中的作用及分子机制研究(82460651),2025年1月-2025年12月,32万元
兵团重点领域科技攻关项目:人体多器官微流控芯片平台的研发及在纳米TiO2毒性研究和新疆特色药物筛选中的应用(2023AB049),2023年10月-2026年10月,220万元
学术论文:
第一或通讯作者发表研究论文50余篇,其中30余篇被SCI\EI收录,主编学数专著3部。近5年通讯作者发表17篇SCI收录研究论文如下:
1.The role of CXCL13 in GC-1 cell cycle arrest induced by titanium dioxide nanoparticles through JAK2/STAT3 signaling pathway. Appl Toxicol. 2024(on line).(通讯作者)
2.Study on the mechanisms of defective spermatogenesis induced by TiO2 NPs based on 3D blood− testis barrier microffuidic chip[J].Toxicology,2024,507:153888 10.1016/j.tox.2024.153888.(通讯作者)
3.Titanium Dioxide Nanoparticles Induce Cell Cycle Arrest andApoptosis through Inhibiting PI3K/AKT/mTOR Pathway in Spermatogonia[J].Biological Trace Element Research, 2024, 202(9).DOI:10.1007/s12011-023-03984-7.(通讯作者)
4.Titanium dioxide nanoparticles induce apoptosis through ROSCa2+-p38/AKT/mTOR pathway in TM4 cells[J]Appl Toxicol. 2024;1–15.DOI: 10.1002/jat.4583.(通讯作者)
5.The status and influencing factors of lung ventilation function in employees exposed to dust in enterprises of the XPCC, China [J].Frontier in Public Heaith,2024,1-18.DOI10.3389/fpubh.2024.1370765.(通讯作者)
6.The ROS Mediates MCUb in Mitochondria‑Regulated Apoptosis of TM4 Cells Induced by Titanium Dioxide Nanoparticles [J].Biological Trace Element Research, 2024,DOI:org/10.1007/s12011-024-04339-6.(通讯作者)
7.The Role of PI3K/AKT/HIF- 1α.Pathway in the Effect of Nano- TiO2 on Lactate Production in TM4 Cells.Journal of Applied Toxicology, 2024; 0:1–11.(通讯作者)
8.Protective Effects of lycopene on TiO2 Nanoparticle-induced Damage in The Liver of Mice[J]. Journal of Applied Toxicology, 2023,43(6):913-928. doi: 10.1002/jat.4433.(通讯作者)
9.Nanosized Titanium Dioxide Induced Apoptosis and Abnormal Expression of Blood-Testis Barrier Junction Proteins Through JNK Signaling Pathway in TM4 Cells[J]. Biological Trace Element Research, 2022, 200(12):5172-5187. doi: 10.1007/s12011-022-03099-5.(通讯作者)
10.Effect of Titanium Dioxide Nanoparticles on Mammalian Cell Cycle In Vitro: A Systematic Review and Meta-Analysis[J]. Chemical Research in Toxicology, 2022, 35(9):1435-1456. doi: 10.1021/acs.chemrestox.1c00402.(通讯作者)
11.Effects of Nano-titanium Dioxide on Calcium Homeostasis in Vivo and in Vitro: A Systematic Review and Meta-analysis [J].Toxicology Mechanisms and Methods, 2022 , 19:1-11. doi:10.1080/15376516.2022.2124137.(通讯作者)
12.Nano-titanium Dioxide Exposure and Autophagy: A Systematic Review and meta-analysis[J].Toxin Reviews, 2022,6:1-12.doi: 10.1080/15569543.2022.2084419.(通讯作者)
13.Genotoxicity Evaluation of Silica Nanoparticles in Murine: A Systematic Review and Meta-analysis[J]. Toxicology Mechanisms and Methods, 2022, 32(1): 1-17. doi: 10.1080/15376516.2021.1965277.(通讯作者)
14.Lycopene Alleviates Titanium Dioxide Nanoparticle-induced Testicular Toxicity by Inhibiting Oxidative Stress and Apoptosis in Mice[J]. Biological Trace Element Research, 2021(on line). doi: 10.1007/s12011-021-02881-1.(通讯作者)
15.Effect of Nano-titanium Dioxide on Blood-Testis Barrier and MAPK Signaling Pathway in Male Mice[J].Biological Trace Element Research, 2021,199:2961-2971. doi:10.1007/s12011-020-02404-4.(通讯作者)
16.Genotoxicity Evaluation of Titanium Dioxide Nanoparticles in Vitro: a Systematic Review of the Literature and Meta-analysis[J]. Biological Trace Element Research,2021, 199: 2057-2076. doi: 10.1007/s12011-020-02311-8
17.Oxidative Damage Induced by Nano-titanium Dioxide in Rats and Mice: a Systematic Review and Meta-analysis[J]. Biological Trace Element Research, 2020, 194(1):184-202. doi: 10.1007/s12011-019-01761-z
承担教学:承担本科生《环境卫生课程》的教学,研究生《环境与健康》课程的教学
导师寄语:
年轻人,你的职责是平整土地,而非焦虑时光。你做三四月的事,在八九月自有答案。