1.个人信息:
姓名:司军强,出生年月:1965年8月,学历:博士研究生,职称:教授。邮箱:sijunqiang11@hotmail.com。通讯地址:石河子大学医学院杏一楼办公室213号
科研学术工作经历与教育背景:
1989年于石河子医学院临床医学本科专业毕业,获得医学学士。
1992年9月-1995年6月在同济医科大学攻读生理学专业硕士,获医学硕士学位。
2000年9月-2003年6月在华中科技大学同济医学院攻读中西医结合基础专业博士,获医学博士学位。
2000年4月-2001年7月,美国俄勒冈健康和科技大学访问学者。
2004年7月-2004年10月,澳大利亚国立大学访问学者。
2001年获得石河子大学硕士生导师招生资格。
2005年获武汉大学博士研究生导师招生资格。
2007年获得华中科技大学博士生导师招生资格。
2012年获得石河子大学博士研究生导师招生资格。
3. 主要研究方向:
主要致力于电生理与膜片钳技术:研究初级感觉传入信息的调制、血管细胞间缝隙连接以及细胞电生理技术本身。
神经生理:研究初级传入信息参与神经病理性痛调节机制,深入研究初级感觉神经元在信号传递与整合中的作用和规律。
血管生理:研究心脑血管疾病的发病机制及内耳微循环与听力障碍。
4. 教学科研成果:
承担本科生《生理学》课程的教学,研究生《血管生理与病理生理学》课程的教学;培养研究生50余人。
(1)教学科研项目:主持 2020-2022 兵团科技创新项目 “新疆不同民族原发性高血压血浆外泌体差异 microRNA 筛选及临床诊断标记物的确立”(项目编号:2020AB019);主持 2022-2025 兵团财政科技计划项目 “T 淋巴细胞缝隙连接蛋白通过 Notch 信号通路调控炎症介导肺动脉高压的研究”(项目编号:2022DZ004)
(2)论文:(1)Zan, Zhou,Wen-Jun, Jiang,Yan-Ping, Wang et al. CD36-mediated ROS/PI3K/AKT signaling pathway exacerbates cognitive impairment in APP/PS1 mice after noise exposure.[J] .Sci Total Environ, 2024, 952: 0.
(2)Tian-Feng, Shi,Zan, Zhou,Wen-Jun, Jiang et al. Hyperglycemia-induced oxidative stress exacerbates mitochondrial apoptosis damage to cochlear stria vascularis pericytes via the ROS-mediated Bcl-2/CytC/AIF pathway.[J] .Redox Rep, 2024, 29: 0.
(3)Tian-Lan, Huang,Wen-Jun, Jiang,Zan, Zhou et al. Quercetin attenuates cisplatin-induced mitochondrial apoptosis via PI3K/Akt mediated inhibition of oxidative stress in pericytes and improves the blood labyrinth barrier permeability.[J] .Chem Biol Interact, 2024, 393: 0.
(4)Zan, Zhou,Wen-Jun, Jiang,Li, Li et al. The effects of noise exposure on hippocampal cognition in C57BL/6 mice via transcriptomics.[J] .Biochem Biophys Res Commun, 2023, 690: 0.
(5)Wen-Jun, Jiang,Zan, Zhou,Yan-Ping, Wang et al. PGC-1α affects cochlear pericytes migration in noise-exposed mice.[J] .Biochem Biophys Res Commun, 2023, 687: 0.
(6)Zan, Zhou,Wen-Jun, Jiang,Li, Li et al. Noise exposure increase apoptosis in the hippocampus of AD mice through the upregulation of CTSS.[J] .Biochem Biophys Res Commun, 2023, 681: 0.
(7)Chen, Q., Kong, L., Xu, Z., Cao, N., Tang, X., Gao, R., Zhang, J., Deng, S., Tan, C., Zhang, M., Wang, Y., Zhang, L., Ma, K., Li, L., & Si, J.. The Role of TMEM16A/ERK/NK-1 Signaling in Dorsal Root Ganglia Neurons in the Development of Neuropathic Pain Induced by Spared Nerve Injury (SNI). Molecular neurobiology, 2021, 58(11), 5772–5789. (*通讯作者)(SCI收录)
(8)Tan CY, Wang YP, Han YY, Lu BH, Ji W, Zhu LC, Wang Y, Shi WY, Shan LY, Zhang L, Ma KT, Li L, Si JQ*. Expression and effect of sodium-potassium-chloride cotransporter on dorsal root ganglion neurons in a rat model of chronic constriction injury. [J] .Neural Regen Res, 2020, 15(5):912-921. (*通讯作者)(SCI收录)
(9)Xu ZZ, Chen QY, Deng SY, Zhang M, Tan CY, Ma KT, Li L, Si JQ*, Zhu LC. 17β-Estradiol Attenuates Neuropathic Pain Caused by Spared Nerve Injury by Upregulating CIC-3 in the Dorsal Root Ganglion of Ovariectomized Rats.[J] .Front Neurosci, 2019, 13: 1205. (*通讯作者)(SCI收录)
(10)Zhou Y, Song J, Wang YP, Zhang AM, Tan CY, Liu YH, Zhang ZP, Wang Y, Ma KT, Li L, Si JQ*. Age associated variation in the expression and function of TMEM16A calcium activated chloride channels in the cochlear stria vascularis of guinea pigs.[J] .Mol Med Rep, 2019, 20: 1593-1604. (*通讯作者)(SCI收录)
(11)Chang YC, Han ZW, Zhang Y, Zhou Y, Feng ZY, Chen L, Li XR, Li L, Si JQ* . G protein-coupled estrogen receptor activation improves contractile and diastolic functions in rat renal interlobular artery to protect against renal ischemia reperfusion injury. Biomedecine & Pharmacotherapie. (*通讯作者)(SCI收录)
(12) Qian YF, Wang Y, Tian WW, Wang S, Zhao L1, Li L, Ma KT,Jun-Qiang, Si... Effects of RMF on BKCa and Kv channels in basilar arterial smooth-muscle cells of SHR. Mol Med Rep. 2017; 16(3):2620-2626.
(13) Wang LJ, Ma KT, Shi WY, Wang YZ, Zhao L, Chen XY, Li XZ, Jiang XW, Zhang ZS, Li L,Jun-Qiang, Si. Enhanced gap junctional channel activity between vascular smooth muscle cells in cerebral artery of spontaneously hypertensive rats. Clin Exp Hypertens. 2017; 39(4):295-305.
(14) Li L, Zhang W, Shi WY, Ma KT, Zhao L, Wang Y, Zhang L, Li XZ, Zhu H, Zhang ZS, Liu WD,Jun-Qiang, Si. The Enhancement of Cx45 Expression and Function in Renal Interlobar Artery of Spontaneously Hypertensive Rats at Different Age. Kidney Blood Pressure Research, 2015, 40: 52-65.
(15) Zhang W, Ma K T, Wang Y, Li L,Jun-Qiang, Si. Inhibitory effect of 18ß-glycyrrhetinic acid on KCI- and PE-induced constriction of rat renal interlobar artery in vitro[J]. Sheng li xue bao: [Acta physiologica Sinica], 2014, 66(2):195-202.
(16) Luo J, Zhang Y M, Ma K T, Li L,Jun-Qiang, Si. Difference in the expression of Kv channel in lymphocytes between spontaneously hypertensive rats and Wistar rats.[J]. 2010, 62(4):382.
(17) Guan B C ,Si JQ, Jiang Z G.Blockade of gap junction coupling by glycyrrhetinic acids in guinea pig cochlear artery: A whole-cell voltage- and current-clamp study[J].British Journal of Pharmacology, 2010, 151(7):1049-1060.
(18) Si JQ, Zhang Z Q, Li C X , et al.Modulatory effect of substance P on GABA-activated currents from rat dorsal root ganglion[u]. Acta Pharmacologica Sinica,2004, 25(5):623.
(19) HuH Z, LiZ W , Si JQ. Evidence for the existence of substance P autoreceptor in the membrane of rat dorsal root ganglion neurons[J]. Neuroscience, 1997, 77(2):535-541.
(20) J Q Si, Z W Li, H Z Hu. Inhibitory effect of baclofen on GABA-induced depolarization and GABA-activated current in primary sensory neuronsy.Neuroscience, 1998, 81(3):821-827.
(21) Jun-Qiang Si, Hui Zhao, Yugin Yang, if. Nitric oxide induces hyperpolarization by opening ATP-sensitive K+ channels in guinea pig spiral modiolar artery[J]. Hear Res, 171(1-2):0-176.
(22) Si J Q, LiZ W, Fan Y Z. Modulatory effect of SP on GABA-and NMDA-activated currents in neurons freshly isolated from rat DRG[J]. 1996.
(3)教材/专著:编写了专著《神经系统氯离子转运体与通道》,于 2015 年由西安交通大学出版社出版。
(4)教学科研获奖:获教育部科技进步二等奖 1 项、自然科学三等奖 1 项、新疆生产建设兵团自然科学优秀学术论文一等奖 1 项、兵团杰出青年科技创新奖 1 项、新疆生产建设兵团科学技术进步奖 1 项、二等奖 2 项、三等奖 1 项。
(5)专利:①一种外周血淋巴细胞连接蛋白43与IL-2和IL-6表达的相关性分析方法 (专利号:201611167672.7)
②一种证明缝隙连接在高血压炎症反应中的作用的试验方法 (专利号:CN106596911B)
③一种密闭性好的吸入麻醉装置 (专利号:CN210009478U
④实验动物灌注装置(专利号:CN205795856U)
5.个人事迹:
1989 年从石河子医学院毕业后,司军强教授扎根边疆,深耕兵团医学教育与神经、血管生理研究。他坚守教学科研一线,教学中因材施教,挖掘学生潜力,主讲《生理学》《心血管生理与病理生理学》等课程;科研上聚焦边疆高发疾病,主持多项各级项目;人才培养方面,累计培育研究生余50人,弟子遍布天山南北及全国,为兵团和全国医疗领域输送大量专业人才,以实干践行边疆医学工作者的使命。