肖晗
学位：博士研究生
职称：研究员
研究领域：内科学-炎症与心血管重构
邮箱：xiaohan@bjmu.edu.cn
通讯地址：石河子大学医学院杏1楼办公室213号
学术兼职情况：
国际心脏研究会（ISHR）中国分会委员会副秘书长
中国药理学会第十三届全国心血管药理专业委员会常务委员
中国药理学会生化与分子药理学专业委员会第七届委员会委员
中华医学会心血管病学分会第十一届委员会基础研究学组委员
中国病理生理学会心血管专业委员会青年委员
科研学术工作经历与教育背景：
1998.9-2003.7 北京大学医学部临床医学专业，学士学位
2003.9-2008.7 北京大学医学部病理生理学专业，博士学位
2008.9-2010.1北京大学第三医院血管医学研究所研究助理
2010.2-2012.9美国加州大学河滨分校生物医学系博士后
2012.12-2017.8北京大学第三医院血管医学研究所助理研究员
2017.8-2021.4北京大学第三医院血管医学研究所副研究员
2021.4-至今北京大学第三医院血管医学研究所研究员
科研项目：
1.国家自然科学基金面上项目（32371158），雌激素在交感应激致心脏损伤中的保护作用及机制，2024/01-2027/12,50万 课题负责人
2.国家自然科学基金重点项目（82030072），运动康复干预交感应激致心脏损伤的作用及机制研究，2021/01-2025/12，297万元，课题负责人
3.国家自然科学基金优秀青年科学基金项目（81822003），炎症与心血管重构，2019/01-2021/12，130万元， 课题负责人
4.国家自然科学基金面上项目（81670205），二甲双胍抑制交感激活引起的心脏炎症反应的机制研究，2017.1-2020.12，60万，课题负责人
5.国家自然科学基金青年基金项目（81300067），二甲双胍抑制心脏纤维化的分子机制，2014.1-2016.12，23万，课题负责人
6.国家重点研发计划工程科学与综合交叉专项“心肌纤维化演变机理探索与无创精准影像评价体系构建”项目，课题一“心肌纤维化发生与演变的机理和靶向分子探针研究”（2021YFF0501401），2021.12-2026.12 ，492.5万，子课题负责人
7.国家重点研发计划“发育编程及其代谢调节”专项 （2023YFA1800902 to H.X）课题二“剧烈应激反应诱导心脑失能和猝死的分子与发育机制”课题，2024.01-2028.12，100万，子课题研究骨干
8.国家重点研发计划“主动健康和老龄化科技应对”重点专项“老年人多病共患临床大数据综合管理共享平台建设及防治策略研究”项目(2020YFC2004704) 课题四“多病共患老年人危重症发病预警和风险预测工具研发”，2020.7-2022.12，30万，子课题研究骨干
学术论文：
1. Mingming Zhao #, Ning Cao #, Huijun Gu #, Jiachao Xu, Wenli Xu, Di Zhang, Tong-You Wade Wei, Kang Wang, Ruiping Guo, Hongtu Cui, Xiaofeng Wang, Xin Guo, Zhiyuan Li, Kangmin He, Zijian Li, Youyi Zhang, John Y-J Shyy, Erdan Dong*, Han Xiao*. AMPK Attenuation of β-Adrenergic Receptor-Induced Cardiac Injury via Phosphorylation of β-Arrestin-1-ser330. Circulation Research. 2024 Aug 30;135(6):651-667.
2. Xiangning Deng#, Hongtu Cui#, Hao Liang#, Xinyu Wang, Haiyi Yu, Jingjia Wang, Wenyao Wang, Dongyang Liu, Youyi Zhang, Erdan Dong*, Yida Tang*, Han Xiao* SARS-CoV-2 spike protein acts as a β-adrenergic receptor agonist: a potential mechanism for cardiac sequelae of long COVID. Journal of internal medicine. 2024;296:291–97.
3. Jimin Wu, Melody Shyy, John-Y-J. Shyy, and Han Xiao* Role of inflammasome in endothelial dysfunction. British journal of pharmacology. 2024 Jul 1. doi: 10.1111/bph.16479. Online ahead of print.
4. Haifan Wang; Xiaojun Du; Youyi Zhang; Han Xiao*. New perspective on the mechanisms of cardiac fibrosis. Sci Bull (Beijing). 2023 Nov 30;68(22):2704-2708.
5. Kang Wang, Yawen Deng, Han Xiao*. Exercise and cardiac fibrosis. Current opinion in physiology, 2023, 31: 100630.
6. Mi Zhang, Akehu Alemasi, Mingming Zhao, Wenli Xu, Youyi Zhang, Wei Gao, Haiyi Yu*, Han Xiao* Exercise Training Attenuates Acute β-Adrenergic Receptor Activation-Induced Cardiac Inflammation via the Activation of AMP-Activated Protein Kinase，Int J Mol Sci . 2023 May 25;24(11):9263.doi: 10.3390/ijms24119263.
7. Di Zhang, Ming-Ming Zhao, Ji-Min Wu, Rui Wang, Gang Xue, Yan-Bo Xue, Ji-Qi Shao, You-Yi Zhang, Er-Dan Dong*, Zhi-Yuan Li*, and Han Xiao*. Dual-omics reveals temporal differences in acute sympathetic stress-induced cardiac inflammation following α1 and β-adrenergic receptors activation, Acta Pharmacol Sin. 2023 Jul;44(7):1350-1365.
8. Xianda Chen, Shuaixing Wang, Wenli Xu, Mingming Zhao, Youyi Zhang, and Han Xiao*. Metformin Directly Binds to Mmp-9 to Improve Plaque Stability J Cardiovasc Dev Dis . 2023 Jan 30;10(2):54. https://dx.doi.org/10.3390/jcdd10020054.
9. Cong, Zhukai, Cui Yang, Zhaojin Zeng, Changyi Wu, Feng Zhao, Ziyuan Shen, Han Xiao*, and Xi Zhu*. α1-adrenoceptor stimulation ameliorates lipopolysaccharide-induced lung injury by inhibiting alveolar macrophage inflammatory responses through NF-κB and ERK1/2 pathway in ARDS, Frontiers In Immunology, 2022.13: 1090773.
10. Na Feng, Haiyi Yu, Yueshen Wang, Youyi Zhang, Han Xiao*, and Wei Gao*. Exercise Training Attenuates Angiotensin Ii-Induced Cardiac Fibrosis by Reducing Pou2f1 Expression. Journal of Sport and Health Science 2023 Jul;12(4):464-476.
11. Guomin Hu, Jimin Wu, Huijun Gu, Xiangning Deng, Wenli Xu, Shan Feng, Shuaixing Wang, Yao Song, Zhengda Pang, Xiuling Deng, Aleksandr Vendrov, Nageswara Madamanchi, Marschall Runge, Xinyu Wang, Youyi Zhang, Han Xiao*, Erdan Dong. Galectin-3-Centered Paracrine Network Mediates Cardiac Inflammation and Fibrosis Upon β-Adrenergic Insult. Sci. China Life Sci. 2023 May;66(5):1067-1078.
12. Shuai-Xing Wang, Ye-Nan Feng, Shan Feng, Ji-Min Wu, Mi Zhang, Wen-Li Xu, You-Yi Zhang, Hai-Bo Zhu*, Han Xiao*, Er-Dan Dong IMM-H007 attenuates isoprenaline-induced cardiac fibrosis through targeting TGFβ1 signaling pathway. Acta Pharmacol Sin. 2022 Oct;43(10):2542-2549.
13. Yiqun Liu, Xiaojin Luo, Youyi Zhang, Zijian Li, Han Xiao*, and Yue Cui*. Electrochemical Protein-Based Biosensors for Creatine Kinase: A Review. IEEE SENSORS JOURNAL.2022 22(11): 10280-10291. https://doi.org/10.1109/JSEN.2022.3167415.
14. Jimin Wu, Erdan Dong, Youyi Zhang, and Han Xiao*, The Role of the Inflammasome in Heart Failure. Front. Physiol., 2021. 12:709703.
15. Lu Tie*, Han Xiao*, Da-Lei Wu*, Ye Yang, Pei Wang, A brief guide to good practices in pharmacological experiments: Western blotting. Acta Pharmacol Sin, 2021. 42(7): p. 1015-1017.
16. Ning Cao # , Jing-Jing Wang #, Ji-Min Wu , Wen-Li Xu , Rui Wang , Xian-da Chen , Ye-Nan Feng , Wen-Wen Cong , You-Yi Zhang *, Han Xiao*, Er-Dan Dong. Glibenclamide alleviates beta adrenergic receptor activation-induced cardiac inflammation. Acta Pharmacologica Sinica. 2022 May;43(5):1243-1250.
17. Mingzhe Li, Jimin Wu, Guomin Hu, Yao Song, Jing Shen, Junzhou Xin, Zijian Li, Wei Liu, Erdan Dong, Ming Xu, Youyi Zhang*, Han Xiao*. Pathological matrix stiffness promotes cardiac fibroblast differentiation through the POU2F1 signaling pathway. Sci. China Life Sci. 2021. 64(2): p. 242-254.
18. Jing Shen#, Jimin Wu#, Guomin Hu, Mingzhe Li, Wenwen Cong, Yenan Feng, Shuaixing Wang, Zijian Li, Ming Xu, Erdan Dong, Youyi Zhang, Han Xiao*. Membrane nanotubes facilitate the propagation of inflammatory injury in the heart upon overactivation of the β-adrenergic receptor. Cell Death Dis. 2020 Nov 7;11(11):958. doi: 10.1038/s41419-020-03157-7.
19. WenliXu，Youyi Zhang，Han Xiao* AMP-activated protein kinase activation: therapeutic potential in human diseases. Science Bulletin, 2019. 64(18): p. 1303-1305.
20. Akehu Alemasi,Ning Cao, XiangboAn, Jimin Wu, Huijun Gu, Haiyi Yu, Yao Song, Huan Wang,Youyi Zhang, Han Xiao*,Wei Gao*. Exercise Attenuates Acute β-Adrenergic Overactivation-Induced Cardiac Fibrosis by Modulating Cytokines. J Cardiovasc Transl Res. 2019 Jun ;12:528–538.
21. Han Xiao#, Hao Li#, Jing-Jing Wang, Jian-Shu Zhang, Jing Shen, Xiang-Bo An, Cong-Cong Zhang, Ji-Min Wu, Yao Song, Xin-Yu Wang, Hai-Yi Yu, Xiang-Ning Deng, Zi-Jian Li, Ming Xu, Zhi-Zhen Lu, Jie Du, Wei Gao, Ai-Hua Zhang, Yue Feng, You-Yi Zhang*. IL-18 cleavage triggers cardiac inflammation and fibrosis upon β-adrenergic insult. European Heart Journal. 2018. Jan;39(1):60-69.
22. Jing Shen(#), Jiang-Hui Zhang(#), Han Xiao(#), Ji-Min Wu, Kang-Min He, Zhi-Zhen Lv, Zi-Jian Li, Ming Xu and You-Yi Zhang(*).Mitochondria are transported along microtubules in membrane nanotubes to rescue distressed cardiomyocytes from apoptosis. Cell Death&Disease, 2018.1.23, 9(2): 81
23. Ruifei Chen, Yenan Feng, Jimin Wu , Yao Song, Hao Li, Qiang Shen, Dan Li, Jianshu Zhang, Zhizhen Lu, Han Xiao*, Youyi Zhang*. Metformin attenuates angiotensin II-induced TGFbeta1 expression by targeting hepatocyte nuclear factor-4-alpha. British journal of pharmacology. 2018 Apr;175(8):1217-1229.
24. Zhongcheng Xu, Jimin Wu, Junzhou Xin, Yenan Feng, Guomin Hu, Jing Shen, Mingzhe Li, Youyi Zhang, Han Xiao*, Li Wang*.β3-adrenergic receptor activation induces TGFβ1 expression in cardiomyocytes via the PKG/JNK/c-Jun pathway. Biochem Biophys Res Commun. 2018 Sep 3;503(1):146-151.
25. Yenan Feng, Shuaixing Wang, Youyi Zhang, Han Xiao*. Metformin attenuates renal fibrosis in both AMPKalpha2-dependent and independent manners. Clinical and experimental pharmacology & physiology. 2017. Jun;44(6):648-655.
26. Yenan Feng, Youyi Zhang, Han Xiao* AMPK and cardiac remodeling. Sci China Life Sci 2018; 61(1):14-23. doi: 10.1007/s11427-017-9197-5
27. Han Xiao, Jianshu Zhang, Zhonghe Xu, Yenan Feng, Mingliang Zhang, Jianli Liu, Ruifei Chen, Jing Shen, Jimin Wu, Zhizhen Lu, Xiaohong Fang, Jingyuan Li，Youyi Zhang. Metformin is a novel suppressor for transforming growth factor (TGF)-beta1. Scientific reports (2016);6:28597
28. Jingjing Wang, Yao Song, Hao Li, Qiang Shen, Jing Shen, Xiangbo An, Jimin Wu, Jianshu Zhang, Yunong Wu, Han Xiao*, Youyi Zhang*. Exacerbated cardiac fibrosis induced by beta-adrenergic activation in old mice due to decreased AMPK activity. Clin Exp Pharmacol Physiol (2016)43, 1029-1037.
29. Han Xiao, Min Lu, Ting Yang Lin, Zhen Chen, Gang Chen, Wei-Chi Wang，Traci Marin, Liang Wen, Brendan Gongol, Wei Sun, Ju Chen, Hsien-Da Huang， Joao H.F. Pedra, David A. Johnson, and John Y-J. Shyy. SREBP2 Activation of NLRP3 Inflammasome in Endothelium Mediates Hemodynamic-Induced Atherosclerosis Susceptibility. Circulation (2013) 128(6), 632-642.
获奖：
Ø 2021年11月 中源协和生命医学奖创新突破奖
Ø 2020年11月 姜必宁奖-杰出青年心脏医师论文奖
Ø 2017年11月 Young Investigator Award (poster presentation) 美国心脏协会AHA 2017年会卫星会China-USA Cardiovascular Symposium
Ø 2017年10月 中国药理学会-施维雅青年药理学家奖
专利：
Ø国内专利：肖晗，张幼怡，李明喆 POU2F1基因表达抑制剂在制备治疗组织纤维化疾病药物中的应用 2021. 发明专利 ZL 202010011105.2
Ø国内专利：张幼怡，肖晗，李明喆，冯晔囡 PAX6基因或其表达产物在制备抑制纤维化的药物中的应用 2021 发明专利 ZL 202010083224.9
Ø国内专利：肖晗，张幼怡，李明喆，胡国民 PAX4基因表达抑制剂在制备抑制纤维化的药物中的应用 2021 发明专利 ZL 202010115236.5
Ø国内专利：肖晗，张幼怡，王秀杰，冯姗，刘鑫一种用于抑制纤维化的小分子药物及其应用 2022 发明专利 ZL 202210436246.8
Ø国内专利：肖晗，张幼怡，王秀杰，冯姗，刘鑫一种用于抑制纤维化的小分子药物及其应用 2022 发明专利 ZL 202210436220.3
