崔晓宾 导师简介
一、照片
二、姓名：崔晓宾
三、性别：男
三、出生年月：1983年7月25日
五、学位、学历：医学博士、博士研究生
六、职称：副教授
七、学术兼职情况
中华医学会病理学分会泌尿男生殖系统学组委员
中国抗癌协会病理专委食管癌协作组委员
中国老年医学学会病理分会青年委员会委员
中华医学会病理分会会员
新疆病理学分会会员
八、基本情况
崔晓宾，医学博士，副教授，硕士生导师。2015年获华中科技大学同济医院肿瘤学博士学位。主要从事医学本科、研究生和留学生教学、科研及临床病理诊断工作。研究方向为肿瘤的病理诊断与分子诊断学研究、新疆地区食管癌发病机制研究。兼任中华医学会病理学分会泌尿男生殖系统学组委员、中国抗癌协会病理专委食管癌协作组委员、中国老年医学学会病理分会青年委员会委员，中华医学会病理分会会员，新疆病理学分会会员。主持国家自然科学基金2项，兵团应用基础研究，石河子大学杰出青年科技人才培育计划项目等10项；参加“十一五”国家科技支撑计划、国际交际合作等多项课题。在SCI收录杂志或中文核刊公开发表论文60余篇，其中以第一作者/通讯作者在SCI收录杂志发表论文22篇（其中JCR 1区7篇）。作为主要参与人获得兵团科技进步一等奖1项（排名第四）。出版专著2部（副主编1部），获得国家发明专利3项。
主持课题：
PLCE1基因调控miR-106b~25基因簇宿主基因MCM7促进食管鳞癌细胞增殖的作用及分子机制研究（国家自然科学基金 81760436，34万，2018/01-2021/12，主持）
PLCE1基因在NMBA诱导小鼠食管上皮恶变中的作用及机制研究（石河子大学国际科技合作推进计划项目 GJHZ201702，30万，2018/01-2020/12，主持）
PLCE1基因调控炎性NF-кB信号通路在新疆哈族食管癌侵袭转移中的作用与机制研究（国家自然科学基金 81460362，47万，2015/01-2018/12，主持）
PLCE1负性调控p53抑制新疆哈族食管癌细胞自噬的作用机制研究（兵团应用基础研究计划项目2016AG020，30万，2016/01 -2018/12，主持）
PLCE1基因对食管癌细胞自噬的作用研究（石河子大学高层次人才科研启动项目，RCZX201533，5万，2016/01-2018/12，主持）
PLCE1基因对食管癌细胞自噬抑制的作用机制初步研究（石河子大学杰出青年培育项目，2015ZRKXJQ02，8万，2016/01 -2018/12，主持，已结题）
联检多种肿瘤相关自身抗体对新疆哈族食管癌早期诊断的评价和应用研究（石河子大学重大科技攻关项目，gxjs2014-zdgg06，15万，2015/01 -2017/12，主持，已结题）
PLCE1及其不同突变体对新疆哈萨克族食管癌侵袭迁移的影响及作用机制（2014/01 -2015/12 石河子大学“优秀青年科技人才培育计划”联合资助立项项目，2013ZRKXYQ-YD19，4万，主持，已结题）
发表文章：
Ningjing Zou#, Lan Yang#, Ling Chen#(共同第一作者), Tingting Li, Tingting Jin, Hao Peng, Shumao Zhang, Dandan Wang, Ranran Li, Chunxia Liu, Jinfang Jiang, Lianghai Wang, Weihua Liang, Jianming Hu, Shugang Li, Chuanyue Wu, Xiaobin Cui,* Yunzhao Chen,* Feng Li*(共同通讯作者). Heterozygote of TAP1 Codon637 decreases susceptibility to HPV infection but increases susceptibility to esophageal cancer among the Kazakh populations. Journal of Experimental & Clinical Cancer Research, 2015, 34(1):70. (SCI, IF=6.451)
Cui X, Chen X, Wang W, Chang A, Yang L, Liu C, Peng H, Wei Y, Liang W, Li S, Wang N, Liu W, Hu J, Zhang W, Wang L, Chen Y, Li F(通讯作者). Epigenetic silencing of miR-203 in Kazakh patients with esophageal squamous cell carcinoma by MassARRAY spectrometry. Epigenetics, 2017, 12(8):698-707. (SCI, IF=4.9)
Xiao-bin Cui, Hao Peng, Ran-ran Li, Jian-qin Mu, LanYang, NaLi, Chun-xia Liu, Jian-ming Hu, Shu-gang Li, Yutao Wei, Laibo-Yin,Hong Zhou, Feng Li,and Yun-zhao Chen*(通讯作者). MicroRNA-34a functions as a tumor suppressor by directly targeting oncogenic PLCE1 in Kazakh esophageal squamous cell carcinoma. Oncotarget, 2017,8(54),92454-92469 (SCI, IF=5.168)
Cui XB#, Li S#, Li TT#(共同第一作者), Peng H, Jin TT, Zhang SM, Liu CX, Yang L, Shen YY, Li SG, Li N, Li Y, Hu JM, Jiang JF, Suo J, Qi Y, Liang WH, Wang LH, Dang HW, Li L, Cao WW, Wei Y, Laibo-Yin, Wu CY, Yuan XL, Zhou H, Zheng Y, Chen YZ*, Li F*(共同通讯作者). Targeting oncogenic PLCE1 by miR-145 impairs tumor proliferation and metastasis of esophageal squamous cell carcinoma. Oncotarget, 2016, 7(2):1777-1795 (SCI, IF=6.3)
Xiao-Bin Cui*, Yan-Xia Tian*, Cai-Pu Chun*, Hao Peng, Chun-Xia Liu, Lan Yang, Jian-Ming Hu, Hua-Hua Xin, Xi Chen, Ning Wang, Yu-Tao Wei, Lai-Bo Yin, Yun-Zhao Chen, Feng Li. Genome-wide screening for genomic aberrations in Kazakh patients with esophageal squamous cell cancer by comparative genomic hybridization.Int J Clin Exp Pathol 2018;11(1):427-437
Xiaobin Cui#, Zhimin Zhao#(共同第一作者), Dong Liu, Tao Guo, Su Li, Jianming Hu, Chunxia Liu, Lan Yang, Yuwen Cao, Jinfang Jiang, Weihua Liang, Wei Liu, Shugang Li, Lianghai Wang, Lidong Wang, Wenyi Gu, Chuanyue Wu, Yunzhao Chen*, Feng Li*(共同通讯作者)Inactivation of miR-34a by aberrant CpG methylation in Kazakh patients with esophageal carcinoma. J Exp Clin Cancer Res. 2014, 33(1):20. (SCI, IF=4.451)
Xiao-bin Cui#, Yao-yuan Shen#, Tingting Jin# (共同第一作者), Su Li, Ting-ting Li, Shu-mao Zhang, Hao Peng, Jian-ming Hu, Chun-xia Liu, Lan Yang, Jing Jin, Jin-Fang Jiang, Wei-hua Liang, Na Li, Zhen-zhu Sun, Shu-gang Li, Chuan-yue Wu, Yun-zhao Chen,* Feng Li*(共同通讯作者). SLC39A6: a potential target for diagnosis and therapy of esophageal carcinoma. J Transl Med, 2015,13:321 (SCI, IF=3.947)
Cui XB#, Zhang SM#(共同第一作者), Xu YX, Dang HW, Liu CX, Wang LH, Yang L, Hu JM, Liang WH, Jiang JF, Li N, Li Y, Chen YZ*, Li F*(共同通讯作者). PFN2, a novel marker of unfavorable prognosis, is a potential therapeutic target involved in esophageal squamous cell carcinoma. J Transl Med. 2016, 14(1):137. (SCI, IF=3.947)
Cui X, Wang K, Yang X, Peng H, Chen X, Xin H, Tian Y, Chen Y, Li F. Comprehensive bioinformation analysis of the miRNA of PLCE1 knockdown in esophageal squamous cell carcinoma. Mol Cell Biochem, 2018,442(1-2):111-127.
Xiaobin Cui, Huahua Xin, Hao Peng and Yunzhao Chen*(通讯作者). Comprehensive bioinformatics analysis of the mRNA profile of PLCE1 knockdown in esophageal squamous cell carcinoma. Mol Med Rep, 2017,16(5):5871-5880. (SCI, IF=1.847)
Hao Peng, Jie Yu, Feng Li, Xiaobin Cui*(通讯作者), Yunzhao Chen*(通讯作者). Decreased vitamin D receptor protein expression is associated with the progression and prognosis of esophageal squamous cell carcinoma: a multi-ethnic cohort study from the Xinjiang, China. Int J Clin Exp Pathol, 2017, 10(2):2340-2350. (SCI, IF=2.242)
Xiao-Bin Cui#, Ran-Ran Li#, Xiao-Li Diao#(共同第一作者), Tao Ren, Hao Peng, Dan-Dan Wang, Bin Wang, Yun-Zhao Chen(通讯作者), Feng Li(通讯作者). Hypermethylation of RASSF1A CpG insland is associated with esophageal squamous cell carcinoma in Kazakh patients. Int J Clin Exp Pathol, 2017,10(2):1765-1773. (SCI, IF=2.242)
Xiao-Bin Cui#, Dan-Dan Wang#(共同第一作者), Hai-Yang Zhang, Ting-Ting Li, Ting-Ting Jin, Hao Peng, Shu-Mao Zhang, Bin Wang, Jie Yu, Chun-Xia Liu, Lan Yang, Jing Jin, Su Li, Jin-Fang Jiang, Wei-Hua Liang, Jian-Ming Hu, Shu-Gang Li, Chuan-Yue Wu, Yun-Zhao Chen*, Feng Li*(共同通讯作者). Tumor necrosis factor-α gene 308G/A polymorphism is not associated with esophageal squamous cell carcinoma risk in Kazakh patients. Int J Clin Exp Pathol, 2015, 8(8):9293-9299 (SCI, IF=2.242)
Xiaobin Cui#, Hao Peng #,(共同第一作者), Jing Jin, Tingting Li, Shumao Zhang, Tingting Jin, Su Li, Chunxia Liu, Weihua Liang, Feng Li, Yunzhao Chen*. RANK overexpression as a novel esophageal cancer marker: validated immunohistochemical analysis of two different ethnicities. Int J Clin Exp Pathol 2015;8(2):2249-2258.
Dong HC#, Cui XB#, Wang LH #(共同第一作者), Li M, Shen YY, Zhu JB, Li CF, Hu JM, Li SG, Yang L, Zhang WJ, Chen YZ, Li F. Type-specific detection of human papillomaviruses in Kazakh esophageal squamous cell carcinoma by genotyping both E6 and L1 genes with MALDI-TOF mass spectrometry. Int J Clin Exp Pathol. 2015, 8(10):13156-65
Man Li#, Xiaobin Cui#(共同第一作者), Yaoyuan Shen, Hongchao Dong, Weihua Liang, Yunzhao Chen, Jianming Hu, Shugang Li, Jing Kong, Hongan Li, Jin Zhao*, Feng Li*(共同通讯作者). ORAOV1 overexpression in esophageal squamous cell carcinoma and esophageal dysplasia: a possible biomarker of progression and poor prognosis in esophageal carcinoma. Human Pathology, 2015,46(5):707-715 (SCI, IF=2.769)
Xiao-bin Cui#, Xue-lian Pang#(共同第一作者), Su Li, Jing Jin, Jian-ming Hu, Lan Yang, Chun-xia Liu, Li Li, Shu Jun Wen, Wei-hua Liang, Yun-zhao Chen*, Feng Li*(共同通讯作者). Elevated expression patterns and tight correlation of the PLCE1 and NF-κB signaling in Kazakh patients with esophageal carcinoma. Medical oncology, 2014, 31(1):791. (SCI, IF=2.647)
Xiaobin Cui, Yunzhao Chen, Lin Liu, Li Li, Jianming Hu, Lan Yang, Weihua Liang, Feng Li*. Heterozygote of PLCE1 rs2274223 increases susceptibility to human papillomavirus infection in patients with esophageal carcinoma among the Kazakh populations. J Med Virol. 2014, 86(4):608-17 (SCI, IF=2.3)
Xiao-Bin Cui, Yun-Zhao Chen, Xue-lian Pang, Wei Liu, Jian-Ming Hu, Shu-Gang Li, Lan Yang, Wen-Jie Zhang, Chun-xia Liu, Yu-wen Cao, Jin-Fang Jiang, Wen-Yi Gu, James Pang, Lei Yang, Xiang-Lin Yuan, Shi-Ying Yu, Feng Li*. Multiple polymorphisms within the PLCE1are associated with esophageal cancer via promoting the gene expression in a Chinese Kazakh population. GENE, 2013,530(2),315–322 (SCI, IF=2.196)
Xiaobin Cui #, Su Li #(共同第一作者), Xuelian Pang, Jing Jin, Jianming Hu, Chunxia Liu, Lan Yang, Jinfang Jiang, Weihua Liang, Jing Suo, Yunzhao Chen*，Feng Li*(共同通讯作者). Significance of elevated ERK expression and its positive correlation with EGFR in Kazakh patients with esophageal squamous cell carcinoma. Int J Clin Exp Pathol.2014,7(4),2382-2391 (SCI, IF=2.242)
Xiao-Bin Cui #, Jing Jin #(共同第一作者), Xue-Lian Pang, Su Li, Chun-Xia Liu, Ting-Ting Li, Hao Peng, Shu-Mao Zhang, Li Li, Wei-Hua Liang, Yunzhao Chen*，Feng Li*(共同通讯作者). A case of blastic plasmacytoid dendritic cell neoplasm with ecchymotic lesions on the whole body. Int J Clin Exp Pathol, 2014;7(7):4391-4399 (SCI, IF=2.242)
Xiao-Bin Cui, Hao Peng, Su Li, Ting-ting Li, Shu-mao Zhang, Jian-ming Hu, Chun-xia Liu, Liang-hai Wang, Jing Suo, Na Li, Li Li, Wei-hua Liang, Yun-Zhao Chen*, Feng Li*(共同通讯作者). Prognostic Value of PLCE1 Expression in Upper Gastrointestinal Cancer: A Systematic Review and Meta-Analysis. Asian Pac J Cancer Prev, 2014, 15 (22), 9661-9666 (SCI, IF=2.514)
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