李冬妹
学位:博士研究生
职称:教授
研究领域:生物化学与分子生物学-1)卡波氏肉瘤相关疱疹病毒致病机制及靶向递药研究;2)胃癌早期诊断与个体化诊疗研究。
邮箱:lidong_abc@126.com
通讯地址:石河子大学医学院杏一楼办公室603号
学术兼职情况:
高等医药院校一流课堂设计与实践联盟理事
(高等学校国家级实验教学示范中心联席会)
科研学术工作经历与教育背景:
1997.9-2002.7 石河子大学医学院临床医学专业,学士学位
2002.9-2005.7 石河子大学医学院生物化学与分子生物学专业,硕士学位
2009.9-2012.7 北京大学医学部生物化学与分子生物学专业,博士学位
2015.12-2016.03,美国内布拉斯加州大学医学中心,访问学者
2016.07-2017.08,美国内布拉斯加州大学林肯分校 博士后
2005.9-至今 就职于石河子大学医学院 负责教学科研工作
科研项目:
1. 国家自然科学基金项目(编号32460038),2025-2028,32万。(国家级核心项目)
2. 国家自然基金:长链非编码RNA PVT1通过真核起始因子EIF4A1促进胃癌侵袭转移的作用和机制研究(编号82160573),2022-2025,34.1万。(国家级核心项目)
3. 国家自然基金项目(编号81760362),2018-2021,33万。(国家级核心项目)
4. 兵团科技合作计划项目(编号2022BC002),2022-2024,93万。(自治区级)
5. 兵团应用基础研究项目(编号2015AG015),2015-2019,30万。(自治区级)
6. 石河子大学国际合作项目(编号GJHZ202102),2022-2024,15万。(校级)
学术论文(15篇代表作):
1.Dongmei Li*. miR-769-3p inhibits cellular proliferation of KSHV-infected SH-SY5Y cells through targeting mTOR. Journal of cancer, 2024; 15(11): 3338-3349.(SCI,收录)
2.Dongmei Li*. Folate-Targeted Nanocarriers Co-Deliver Ganciclovir and miR-34a-5p for Combined Anti-KSHV Therapy. Int. J. Mol. Sci. 2024, 25, 2932.(SCI,收录)
3.Dongmei Li*. Targeted delivery of miR-34a-5p by phenylborate-coupled polyethylenimide nanocarriers for anti-KSHV treatment. Frontiers in Bioengineering and Biotechnology, 2024,11:1-12. (SCI,收录)
4.Dongmei Li*.Eukaryotic translation initiation factor 4A1 in the pathogenesis and treatment of cancers. Frontiers in molecular biosciences. 2023(11):1-9. (SCI,收录)
5.Dongmei Li*. An Essential Role of c-Fos in Notch1-Mediated Promotion of Proliferation of KSHV-Infected SH-SY5Y Cells. Current Molecular Pharmacology.2024,17: 1874. (SCI,收录)
6.Dongmei Li*. Exploring the molecular landscape of osteosarcoma through PTTG family genes using a detailed multi-level methodology. Frontiers in Genetics, 2024.1431668. (SCI,收录)
7.Dongmei Li*. Delivery of miR-34a-5p by Folic Acid Modified β-cyclodextrin Grafted Polyethylenimine Copolymer Nanocarriers to Resist KSHV. ACS Applied Nano Materials. 2023, 6, 10826-10836. (SCI,收录)
8.Dongmei Li*. Eukaryotic translation initiation factor4A1 in the pathogenesis and treatment of cancers. Frontiers in molecular biosciences. 2023(11):1-9. (SCI,收录)
9.Dongmei Li*. Kaposi’s sarcoma-associated herpesvirus infection promotes proliferation of SH-SY5Y cells by the Notch signaling pathway. Cancer Cell Int. (2021) 21:577.(SCI,收录)
10.Dongmei Li*. HPV16 E6 gene polymorphisms and the functions of the mutation site in cervical cancer among Uygur ethnic and Han nationality women in Xinjiang, China. Cancer Cell International (2022) 22:94. (SCI,收录)
11.Dongmei Li*. Study of miR-34a-5p inhibiting the malignant progression of KSHV-infected SH-SY5Y cells by targeting c-fos. Peer J (2022):13233.(SCI,收录)
12.Dongmei Li*. Bone Marrow Derived SH-SY5Y Neuroblastoma Cells Infected by Kaposi’s Sarcoma Herpes Virus (KSHV) Display Unique Infection Phenotypes and Growth Properties. J Virol,2021,95(13):e00003-21.(SCI,收录)
13.Dongmei Li*. Parthenolide inhibits proliferation of cells infected with Kaposi’s sarcomaassociated herpesvirus by suppression of the NFκB signaling pathway,Archives of Virology (2023) 168:39.(SCI,收录)
14.Dongmei Li*. Analysis of genetic variation in human papillomavirus type 16 E1 and E2 in women with cervical infection in Xinjiang, China. BMC Medical Genomics (2021) 14:268.(SCI,收录)
15.Dongmei Li*. High Expression of long non-coding RNA PVT1 predicts metastasis in Han and Uygur Patients with Gastric Cancer in Xinjiang, China. Scientific Reports. 2019(9):548-559.(SCI,收录)
获奖:石河子大学学科带头人,优秀青年教师,“3152”青年骨干教师,石河子大学优秀硕士论文指导教师,全国大学生基础医学创新研究暨实验设计大赛优秀指导教师,国家级大学生优秀项目指导教师,石河子大学优秀工会积极分子,石河子大学医学院“优秀共产党员”等称号。指导学生获得指导学生参加全国大学生基础医学创新研究大赛获国家级银奖、铜奖各一项,省级二等奖三项。获得石河子大学教学成果二等奖。参与获得省级科技进步奖二等奖1项,三等奖1项,石河子大学教学成果一等奖和研究生教学成果二等奖各1项。
承担教学:承担本科生《生物化学》《Biochemistry》课程的教学,研究生《医学生物化学与分子生物学》《现代细胞与组化技术》等课程的教学。